Complete Pathologic Response to Neoadjuvant Chemoimmunotherapy and Oxaliplatin-Induced Fever Associated With IL-6 Release in a Patient With Locally Advanced Colon Cancer

Neoadjuvant systemic therapy is a preferred treatment approach for number of tumor types due to many potential advantages over upfront surgery, including downstaging, early micrometastatic disease, and providing an in vivo test biology. For colon cancer, current standard care surgery followed by adjuvant high-risk patients. Concerns about inaccurate radiological staging progression during preoperative treatment, as well the lack randomized data demonstrating benefit, are among reasons limited use neoadjuvant this disease. Locally advanced defined primary cancer with direct invasion into adjacent structures or extensive regional lymph node involvement, not always amenable pathological complete resection, when attempted it comes high incidence postoperative morbidity mortality because required multivisceral resection. Clinical trials chemotherapy date have been promising downstaging disease higher rates R0 Here, we report case patient locally advanced, unresectable, mismatch repair deficient sigmoid who was treated chemoimmunotherapy surgical resection leading pathologic response after chemoimmunotherapy.